{"id":1769,"date":"2025-05-24T18:52:53","date_gmt":"2025-05-24T15:52:53","guid":{"rendered":"https:\/\/sonerduzguner.com\/?p=1769"},"modified":"2025-09-16T16:55:01","modified_gmt":"2025-09-16T13:55:01","slug":"is-polycystic-ovary-syndrome-dangerous","status":"publish","type":"post","link":"https:\/\/www.sonerduzguner.com\/en\/is-polycystic-ovary-syndrome-dangerous\/","title":{"rendered":"Is Polycystic Ovary Syndrome Dangerous?"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><div      class=\"vc_row wpb_row section vc_row-fluid\" style=' padding-bottom:40px; text-align:left;'><div class=\"full_section_inner clearfix\"><div class=\"wpb_column vc_column_container vc_col-sm-12\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\">\n\t<div class=\"wpb_single_image wpb_content_element vc_align_left\">\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t\n\t\t\t<div class=\"vc_single_image-wrapper   vc_box_border_grey\"><img loading=\"lazy\" decoding=\"async\" width=\"955\" height=\"346\" src=\"https:\/\/www.sonerduzguner.com\/wp-content\/uploads\/2025\/05\/polikistik-over-sendromu-tehlikeli-mi-1.jpg\" class=\"vc_single_image-img attachment-full\" alt=\"\" title=\"polikistik-over-sendromu-tehlikeli-mi-1\" srcset=\"https:\/\/www.sonerduzguner.com\/wp-content\/uploads\/2025\/05\/polikistik-over-sendromu-tehlikeli-mi-1.jpg 955w, https:\/\/www.sonerduzguner.com\/wp-content\/uploads\/2025\/05\/polikistik-over-sendromu-tehlikeli-mi-1-300x109.jpg 300w, https:\/\/www.sonerduzguner.com\/wp-content\/uploads\/2025\/05\/polikistik-over-sendromu-tehlikeli-mi-1-768x278.jpg 768w, https:\/\/www.sonerduzguner.com\/wp-content\/uploads\/2025\/05\/polikistik-over-sendromu-tehlikeli-mi-1-18x7.jpg 18w, https:\/\/www.sonerduzguner.com\/wp-content\/uploads\/2025\/05\/polikistik-over-sendromu-tehlikeli-mi-1-700x254.jpg 700w\" sizes=\"auto, (max-width: 955px) 100vw, 955px\" \/><\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div><\/div><\/div><\/div><\/div><div      class=\"vc_row wpb_row section vc_row-fluid\" style=' text-align:left;'><div class=\"full_section_inner clearfix\"><div class=\"blog-detay wpb_column vc_column_container vc_col-sm-12\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\">\n\t<div class=\"wpb_text_column wpb_content_element\">\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t<p>Polycystic Ovary Syndrome (PCOS) is the most common endocrine disorder in women. Its prevalence varies among populations and is approximately between 15\u201318%. Clinical manifestations are variable...<\/p>\n<h2><span class=\"ez-toc-section\" id=\"i\"><\/span>Polycystic Ovary Syndrome Diagnostic Criteria and Phenotypes<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The most common signs of Polycystic Ovary Syndrome are as follows:<\/p>\n<ul>\n<li>Oligo\/anovulation<\/li>\n<li>Hyperandrogenism (Clinical\/biochemical)<\/li>\n<li>Polycystic Ovary Morphology (PCOM)<\/li>\n<\/ul>\n<p class=\"translation-block\"><strong>Oligo\/anovulation<\/strong> is defined as having 35 or more days between two menstruations (periods), or no menstruation for 200 days (approximately 6 months).<\/p>\n<p class=\"translation-block\"><strong>Hyperandrogenism<\/strong> should be defined as the detection of one of the following findings on physical examination: hirsutism (male-pattern hair growth on the body), acne (pimple formation), or alopecia (male-pattern hair loss), or an increase in the levels of one of the androgen hormones: free testosterone (sT), dehydroepiandrosterone (DHEAS), and androstenedione (A4).<\/p>\n<p>The most common finding of <strong>Clinical Hyperandrogenism<\/strong> in PCOS is Hirsutism. Hirsutism is diagnosed by scoring hair growth in nine different body regions according to the Ferriman-Gallway Scale. A score above 8 is considered Hirsutism.<\/p>\n<p class=\"translation-block\"><strong>Polikistik Over Morfolojisi<\/strong>, over (yumurtal\u0131k) korteksinde inci tanesi \u015feklinde dizilmi\u015f en az 12 tane 2-9 mm \u00e7ap\u0131nda follik\u00fcl veya artm\u0131\u015f over vol\u00fcm\u00fc &gt;10 ml olarak tan\u0131mlan\u0131r. (\u015eekil 1 \u2013 2).<\/p>\n<p><strong>Figure 1<\/strong>: Tipik PKOS g\u00f6r\u00fcn\u00fcm\u00fc kortekste inci tanesi gibi dizilmi\u015f k\u00fc\u00e7\u00fck folik\u00fcller ve artm\u0131\u015f hiperekojen stroma.<\/p>\n<p class=\"translation-block\"><strong>Figure 2<\/strong>: 3D (three-dimensional) Polycystic Ovary Morphology in ultrasonography<\/p>\n<p>Currently, as recommended by the NIH (National Institutes of Health) and ASRM\/ESHRE (American Society for Reproductive Medicine \/ European Society of Human Reproduction and Embryology), Polycystic Ovary Syndrome is diagnosed by the presence of at least two of the following findings: oligo\/anovulation, hyperandrogenism, and polycystic ovary morphology.<\/p>\n<p>Obesity, insulin resistance, hyperinsulinemia, high LH levels, and a high LH\/FSH ratio are also important findings that can accompany this syndrome.<\/p>\n<p>In patients where we suspect Polycystic Ovary Syndrome, it's crucial to differentiate it from other diseases that mimic its characteristics. This ensures the correct approach and treatment for the patient. The diseases to consider in differential diagnosis, along with important diagnostic tests, are listed below.<\/p>\n<p><strong>Androgen-secreting tumors<\/strong><\/p>\n<p class=\"translation-block\">Testosteron &gt; 200 ng\/dl<br>\r\nDHEA-S &gt;700 mcg\/dl<\/p>\n<p><strong>HAIR-AN syndrome<\/strong><\/p>\n<p class=\"translation-block\">Basal fasting insulin &gt; 25 \u03bcIU\/ml, 2nd hour OGTT &gt; 300 \u03bcIU\/ml<br> Testosterone &gt; 150 ng\/dl<\/p>\n<p><strong>Cushing's Syndrome<\/strong><\/p>\n<p class=\"translation-block\">24-hour urinary free cortisol (&gt;300 \u03bcg)<br> Hypo\/hyperthyroidism<br> TSH &gt;4 mIU\/L<\/p>\n<p><strong>Hyperprolactinemia<\/strong><\/p>\n<p>Prolactin &gt;24 ng\/mL<\/p>\n<p><strong>Non-classic Adrenal Hyperplasia<\/strong><\/p>\n<p>Basal serum 17-OHP (&gt; 200 ng\/dL)\u2014ACTH stim test<\/p>\n<p>The form (Figure 3) showing the ovarian morphology, oligo\/anovulation, and hyperandrogenism parameters that we evaluate in our center for the diagnosis of PCOS.<\/p>\n<p class=\"translation-block\"><strong>Figure 3<\/strong>: <strong>Parameters evaluated in the approach to PCOS diagnosis.<\/strong><\/p>\n<p class=\"translation-block\"><strong>Table 1<\/strong>. <strong>Phenotyping according to PCOS Diagnostic Criteria<\/strong><\/p>\n<p>Infertility is a common presenting complaint for women with PCOS. Although the primary cause of infertility appears to be oligo\/anovulation, endometrial changes hindering implantation (embryo attachment) and obesity are also factors contributing to infertility.<\/p>\n<p>For women with Polycystic Ovary Syndrome presenting with infertility, if no other cause is found, management of PCOS-related infertility is necessary.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"i-2\"><\/span>PCOS-related Infertility Management<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p class=\"translation-block\"><strong>Lifestyle modification<\/strong> is the first-line treatment for both obese and lean women with PCOS. The combination of diet and exercise improves the hormonal profile, increases the response to assisted reproductive technology treatments, and reduces the risk of complications during pregnancy.<\/p>\n<p class=\"translation-block\"><strong>Clomiphene citrate (CC)<\/strong> is the first-line pharmacological treatment for ovulation induction (ovarian stimulation phase). It is started between days 2-5 of the menstrual cycle. A 5-day treatment is planned with a starting dose of 50mg\/day.<\/p>\n<p class=\"translation-block\"><strong>Aromatase Inhibitors<\/strong> can be preferred as a first-line treatment option in cases of clomiphene citrate failure or resistance. They are started between days 3-7 of the menstrual cycle. A 5-day treatment is planned with a starting dose of 2.5mg\/day.<\/p>\n<p class=\"translation-block\"><strong>Metformin<\/strong> is an insulin-sensitizing agent that helps improve PCOS symptoms. When started 3 months before fertility treatment and continued for 9 months after the treatment begins, it contributes to higher pregnancy and live birth rates.<\/p>\n<p class=\"translation-block\"><strong>Gonadotropins<\/strong> are used as a second-line treatment in cases of clomiphene citrate failure or resistance. They are started between days 2-5 of the menstrual cycle. Low-dose treatment is planned to reduce the risk of ovarian hyperstimulation and multiple pregnancies.<\/p>\n<p class=\"translation-block\"><strong>In-vitro fertilization (IVF)<\/strong> is considered a third-line treatment for PCOS-related infertility. It should be preferred when there is no response to ovulation induction treatments or when additional infertility factors are present.<\/p>\n\n\t\t<\/div>\n\t<\/div><\/div><\/div><\/div><\/div><\/div><div      class=\"vc_row wpb_row section vc_row-fluid  sizi-arayalim vc_custom_1748634280261\" style=' text-align:left;'><div class=\"full_section_inner clearfix\"><div class=\"wpb_column vc_column_container vc_col-sm-12\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div      class=\"vc_row wpb_row section vc_row-fluid vc_inner\" style=' text-align:left;'><div class=\"full_section_inner clearfix\"><div class=\"wpb_column vc_column_container vc_col-sm-12\"><div class=\"vc_column-inner vc_custom_1746548174605\"><div class=\"wpb_wrapper\">\n\t<div class=\"wpb_text_column wpb_content_element\">\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t<h2><span class=\"ez-toc-section\" id=\"i-3\"><\/span><span style=\"color: #ffffff;\">Let Us Call You<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\t\t<\/div>\n\t<\/div><div class=\"vc_empty_space\"  style=\"height: 15px\" >\n\t<span class=\"vc_empty_space_inner\">\n\t\t<span class=\"empty_space_image\"  ><\/span>\n\t<\/span>\n<\/div>\n\t<div class=\"wpb_text_column wpb_content_element\">\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t<p><span style=\"color: #ffffff;\">Let us reach you quickly about the topics you want to consult.<\/span><\/p>\n\n\t\t<\/div>\n\t<\/div><div class=\"vc_empty_space\"  style=\"height: 15px\" >\n\t<span class=\"vc_empty_space_inner\">\n\t\t<span class=\"empty_space_image\"  ><\/span>\n\t<\/span>\n<\/div>\n<div class=\"wpcf7 no-js\" id=\"wpcf7-f1517-o1\" lang=\"en-US\" dir=\"ltr\" data-wpcf7-id=\"1517\">\n<div class=\"screen-reader-response\"><p role=\"status\" aria-live=\"polite\" aria-atomic=\"true\"><\/p> <ul><\/ul><\/div>\n<form action=\"\/en\/wp-json\/wp\/v2\/posts\/1769#wpcf7-f1517-o1\" method=\"post\" class=\"wpcf7-form init cf7_custom_style_1\" aria-label=\"Contact form\" novalidate=\"novalidate\" data-status=\"init\" data-trp-original-action=\"\/en\/wp-json\/wp\/v2\/posts\/1769#wpcf7-f1517-o1\">\n<fieldset class=\"hidden-fields-container\"><input type=\"hidden\" name=\"_wpcf7\" value=\"1517\" \/><input type=\"hidden\" name=\"_wpcf7_version\" value=\"6.1.6\" \/><input type=\"hidden\" name=\"_wpcf7_locale\" value=\"en_US\" \/><input type=\"hidden\" name=\"_wpcf7_unit_tag\" value=\"wpcf7-f1517-o1\" \/><input type=\"hidden\" name=\"_wpcf7_container_post\" value=\"0\" \/><input type=\"hidden\" name=\"_wpcf7_posted_data_hash\" value=\"\" \/><input type=\"hidden\" name=\"_wpcf7_recaptcha_response\" value=\"\" \/>\n<\/fieldset>\n<div class=\"mobil-full-form\"  style=\"width:70%; 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Dr. Soner D\u00dcZG\u00dcNER<\/h4>\n\n\t\t<\/div>\n\t<\/div>\n\t<div class=\"wpb_text_column wpb_content_element  blog-detay-unvan\">\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t<p>Obstetrics and Gynaecology Specialist<\/p>\n\n\t\t<\/div>\n\t<\/div><div class=\"vc_empty_space\"  style=\"height: 5px\" >\n\t<span class=\"vc_empty_space_inner\">\n\t\t<span class=\"empty_space_image\"  ><\/span>\n\t<\/span>\n<\/div>\n\t<div class=\"wpb_text_column wpb_content_element  blog-detay-unvan-desc\">\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t<p>Op. Dr. Soner D\u00fczg\u00fcner: Provides diagnosis and treatment in areas such as in vitro fertilization, women's health, infertility, gynecological surgery and pregnancy follow-up.<\/p>\n\n\t\t<\/div>\n\t<\/div><div class=\"vc_empty_space\"  style=\"height: 15px\" >\n\t<span class=\"vc_empty_space_inner\">\n\t\t<span class=\"empty_space_image\"  ><\/span>\n\t<\/span>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Polikistik Over Sendromu (PKOS), kad\u0131nlarda en s\u0131k g\u00f6r\u00fclen endokrin hastal\u0131kt\u0131r.<\/p>","protected":false},"author":1,"featured_media":1355,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1769","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog-icerikleri"],"_links":{"self":[{"href":"https:\/\/www.sonerduzguner.com\/en\/wp-json\/wp\/v2\/posts\/1769","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.sonerduzguner.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.sonerduzguner.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.sonerduzguner.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.sonerduzguner.com\/en\/wp-json\/wp\/v2\/comments?post=1769"}],"version-history":[{"count":10,"href":"https:\/\/www.sonerduzguner.com\/en\/wp-json\/wp\/v2\/posts\/1769\/revisions"}],"predecessor-version":[{"id":3079,"href":"https:\/\/www.sonerduzguner.com\/en\/wp-json\/wp\/v2\/posts\/1769\/revisions\/3079"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.sonerduzguner.com\/en\/wp-json\/wp\/v2\/media\/1355"}],"wp:attachment":[{"href":"https:\/\/www.sonerduzguner.com\/en\/wp-json\/wp\/v2\/media?parent=1769"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.sonerduzguner.com\/en\/wp-json\/wp\/v2\/categories?post=1769"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.sonerduzguner.com\/en\/wp-json\/wp\/v2\/tags?post=1769"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}