{"id":3348,"date":"2026-01-03T11:25:54","date_gmt":"2026-01-03T08:25:54","guid":{"rendered":"https:\/\/www.sonerduzguner.com\/?p=3348"},"modified":"2026-02-19T11:57:16","modified_gmt":"2026-02-19T08:57:16","slug":"the-story-of-zanan-ivf-and-the-importance-of-correct-embryo-selection-in-a-family-with-high-genetic-risk","status":"publish","type":"post","link":"https:\/\/www.sonerduzguner.com\/en\/the-story-of-zanan-ivf-and-the-importance-of-correct-embryo-selection-in-a-family-with-high-genetic-risk\/","title":{"rendered":"Zana\u2019s Story: The Importance of IVF and Correct Embryo Selection in a High Genetic Risk Family"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><div      class=\"vc_row wpb_row section vc_row-fluid\" style=' padding-bottom:40px; text-align:left;'><div class=\"full_section_inner clearfix\"><div class=\"wpb_column vc_column_container vc_col-sm-12\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\">\n\t<div class=\"wpb_single_image wpb_content_element vc_align_left\">\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t\n\t\t\t<div class=\"vc_single_image-wrapper   vc_box_border_grey\"><img loading=\"lazy\" decoding=\"async\" width=\"921\" height=\"507\" src=\"https:\/\/www.sonerduzguner.com\/wp-content\/uploads\/2026\/01\/WhatsApp-Image-2026-01-03-at-15.17.10.jpeg\" class=\"vc_single_image-img attachment-full\" alt=\"\" title=\"WhatsApp Image 2026-01-03 at 15.17.10\" srcset=\"https:\/\/www.sonerduzguner.com\/wp-content\/uploads\/2026\/01\/WhatsApp-Image-2026-01-03-at-15.17.10.jpeg 921w, https:\/\/www.sonerduzguner.com\/wp-content\/uploads\/2026\/01\/WhatsApp-Image-2026-01-03-at-15.17.10-300x165.jpeg 300w, https:\/\/www.sonerduzguner.com\/wp-content\/uploads\/2026\/01\/WhatsApp-Image-2026-01-03-at-15.17.10-768x423.jpeg 768w, https:\/\/www.sonerduzguner.com\/wp-content\/uploads\/2026\/01\/WhatsApp-Image-2026-01-03-at-15.17.10-18x10.jpeg 18w, https:\/\/www.sonerduzguner.com\/wp-content\/uploads\/2026\/01\/WhatsApp-Image-2026-01-03-at-15.17.10-700x385.jpeg 700w\" sizes=\"auto, (max-width: 921px) 100vw, 921px\" \/><\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div><\/div><\/div><\/div><\/div><div      class=\"vc_row wpb_row section vc_row-fluid\" style=' text-align:left;'><div class=\"full_section_inner clearfix\"><div class=\"blog-detay wpb_column vc_column_container vc_col-sm-12\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\">\n\t<div class=\"wpb_text_column wpb_content_element\">\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t<p class=\"translation-block\">Some IVF treatments require managing not only infertility but also intergenerational genetic risks.<\/p>\n<p>Zana\u2019s story is the result of exactly such a process.<\/p>\n<p><strong>A Journey Beginning with High Genetic Risk<\/strong><\/p>\n<p class=\"translation-block\">Anne ve baba adaylar\u0131 <strong>amca \u00e7ocuklar\u0131<\/strong>yd\u0131 ve her ikisi de, n\u00f6rolojik hastal\u0131klarla ili\u015fkili <strong>\u00fc\u00e7 farkl\u0131 genetik mutasyonun ta\u015f\u0131y\u0131c\u0131s\u0131yd\u0131<\/strong>:<\/p>\n<ul>\n<li><strong>NPHS2<\/strong><\/li>\n<li><strong>ADPRS<\/strong><\/li>\n<li><strong>MUTYH<\/strong><\/li>\n<\/ul>\n<p class=\"translation-block\">Bu genetik yap\u0131 nedeniyle \u00e7iftin, genetik hastal\u0131ktan <strong>etkilenmi\u015f ve halen ya\u015fayan \u00fc\u00e7 \u00e7ocu\u011fu<\/strong> bulunuyordu.<\/p>\n<p>In addition, there was a history of consanguineous marriages in the mother\u2019s family;<\/p>\n<p class=\"translation-block\">anne aday\u0131n\u0131n k\u0131z karde\u015finde, <strong>kas hastal\u0131\u011f\u0131 nedeniyle kaybedilmi\u015f bir \u00e7ocuk \u00f6yk\u00fcs\u00fc<\/strong> bulunuyordu.<\/p>\n<p>For this reason, the planned new pregnancy was not only about the desire to have a baby,<\/p>\n<p class=\"translation-block\"><strong>sa\u011fl\u0131kl\u0131 bir \u00e7ocuk d\u00fcnyaya getirme sorumlulu\u011funu<\/strong> da i\u00e7eriyordu.<\/p>\n<p><strong>Initial Evaluation and Treatment Plan<\/strong><\/p>\n<p class=\"translation-block\">The first consultation with the couple took place in 2023.<\/p>\n<p class=\"translation-block\">The risks were analyzed in detail, and it was clear that a conventional IVF approach would not be sufficient.<\/p>\n<p>In this case, the goal was:<\/p>\n<ul>\n<li>Not only to achieve pregnancy,<\/li>\n<li class=\"translation-block\">But to identify a genetically healthy embryo before pregnancy.<\/li>\n<\/ul>\n<p><strong>IVF and Genetic Testing Process<\/strong><\/p>\n<p class=\"translation-block\">IVF treatment was performed in 2024.<\/p>\n<ul>\n<li class=\"translation-block\">A total of 19 oocytes were retrieved<\/li>\n<li class=\"translation-block\">7 day-5 (D5) embryos developed<\/li>\n<li>Biopsy samples were taken from these embryos<\/li>\n<\/ul>\n<p class=\"translation-block\">Preimplantation genetic testing (PGT) was performed for the NPHS2, ADPRS, and MUTYH genes<\/p>\n<p>Among the embryos analyzed:<\/p>\n<ul>\n<li class=\"translation-block\">Embryos that were genetically healthy or only carriers were identified<\/li>\n<\/ul>\n<p class=\"translation-block\">Subsequently, chromosomal analysis (PGT-A) was applied to 2 selected embryos:<\/p>\n<ul>\n<li class=\"translation-block\">1 embryo: Normal chromosomal structure<\/li>\n<li>1 embriyo: <strong>%35 oran\u0131nda mozaik monozomi 9<\/strong><\/li>\n<\/ul>\n<p><strong>Embryo Transfers and Endometrial Preparation<\/strong><\/p>\n<ol>\n<li><strong> Second Attempt<\/strong><\/li>\n<\/ol>\n<ul>\n<li class=\"translation-block\">The endometrium was prepared using an artificial protocol (with estradiol)<\/li>\n<li><strong>An embryo with normal chromosomes,<\/strong>,<\/li>\n<\/ul>\n<p><strong>genetically healthy for NPHS2,<\/strong>,<\/p>\n<p class=\"translation-block\">and not a carrier for ADPRS and MUTYH was transferred<\/p>\n<ul>\n<li><strong>Pregnancy was not achieved<\/strong><\/li>\n<\/ul>\n<ol start=\"2\">\n<li><strong> Second Attempt<\/strong><\/li>\n<\/ol>\n<ul>\n<li class=\"translation-block\">This time, the endometrium was prepared using a natural protocol<\/li>\n<li><strong>%35 mozaik monozomi 9<\/strong> i\u00e7eren,<\/li>\n<\/ul>\n<p class=\"translation-block\">genetically healthy for all three genes, was transferred<\/p>\n<ul>\n<li><strong>Pregnancy was achieved<\/strong><\/li>\n<\/ul>\n<p class=\"translation-block\">This stage once again demonstrated that endometrial preparation can respond differently in each patient and depending on the embryo.<\/p>\n<p><strong>Outcome: The Birth of Zana<\/strong><\/p>\n<p>Zana,<\/p>\n<p><strong>Zana was born in France on the night of December 31,<\/strong>,<\/p>\n<p>as one of the last babies of 2025,<\/p>\n<p class=\"translation-block\">and her birth was also covered by the French press.<\/p>\n<p>Today, Zana is:<\/p>\n<ul>\n<li class=\"translation-block\">A source of support for her three siblings affected by genetic disease,<\/li>\n<li class=\"translation-block\">For her mother, both a healthy child and a lifelong companion,<\/li>\n<li class=\"translation-block\">And for her family, a tangible symbol of hope and trust.<\/li>\n<\/ul>\n<p><strong>The Most Important Message from This Case<\/strong><\/p>\n<p>For some families, IVF treatment is not about:<\/p>\n<ul>\n<li>The number of eggs,<\/li>\n<li>Or the number of embryos.<\/li>\n<\/ul>\n<p>For certain families, IVF requires:<\/p>\n<ul>\n<li>Genetic science,<\/li>\n<li>Experience,<\/li>\n<li class=\"translation-block\">Patient planning, and ethical responsibility\u2014all together.<\/li>\n<\/ul>\n<p>With the right center, the right strategy, and an individualized approach,<\/p>\n<p>IVF treatment<\/p>\n<p class=\"translation-block\">can turn into a journey that changes a family\u2019s destiny.<\/p>\n<p><strong>Information Note<\/strong><\/p>\n<p>This article is for informational purposes only.<\/p>\n<p>Each patient and each genetic risk profile is unique; diagnosis and treatment must always be planned through individualized evaluation.<\/p>\n\n\t\t<\/div>\n\t<\/div><div class=\"vc_empty_space\"  style=\"height: 15px\" >\n\t<span class=\"vc_empty_space_inner\">\n\t\t<span class=\"empty_space_image\"  ><\/span>\n\t<\/span>\n<\/div>\n\t<div class=\"wpb_text_column wpb_content_element\">\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t<p>https:\/\/www.lunion.fr\/archives\/recherche?word=zana&sort=date+desc&datefilter=lastyear<\/p>\n\n\t\t<\/div>\n\t<\/div><\/div><\/div><\/div><\/div><\/div><div      class=\"vc_row wpb_row section vc_row-fluid  sizi-arayalim vc_custom_1748634241618\" style=' text-align:left;'><div class=\"full_section_inner clearfix\"><div class=\"wpb_column vc_column_container vc_col-sm-12\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div      class=\"vc_row wpb_row section vc_row-fluid vc_inner\" style=' text-align:left;'><div class=\"full_section_inner clearfix\"><div 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Dr. Soner D\u00dcZG\u00dcNER<\/h4>\n\n\t\t<\/div>\n\t<\/div>\n\t<div class=\"wpb_text_column wpb_content_element  blog-detay-unvan\">\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t<p>Obstetrics and Gynaecology Specialist<\/p>\n\n\t\t<\/div>\n\t<\/div><div class=\"vc_empty_space\"  style=\"height: 5px\" >\n\t<span class=\"vc_empty_space_inner\">\n\t\t<span class=\"empty_space_image\"  ><\/span>\n\t<\/span>\n<\/div>\n\t<div class=\"wpb_text_column wpb_content_element  blog-detay-unvan-desc\">\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t<p>Op. Dr. Soner D\u00fczg\u00fcner: Provides diagnosis and treatment in areas such as in vitro fertilization, women's health, infertility, gynecological surgery and pregnancy follow-up.<\/p>\n\n\t\t<\/div>\n\t<\/div><div class=\"vc_empty_space\"  style=\"height: 15px\" >\n\t<span class=\"vc_empty_space_inner\">\n\t\t<span class=\"empty_space_image\"  ><\/span>\n\t<\/span>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"<p class=\"translation-block\">Some IVF treatments require managing not only infertility but also intergenerational genetic risks.<\/p>","protected":false},"author":1,"featured_media":3354,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-3348","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog-icerikleri"],"_links":{"self":[{"href":"https:\/\/www.sonerduzguner.com\/en\/wp-json\/wp\/v2\/posts\/3348","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.sonerduzguner.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.sonerduzguner.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.sonerduzguner.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.sonerduzguner.com\/en\/wp-json\/wp\/v2\/comments?post=3348"}],"version-history":[{"count":9,"href":"https:\/\/www.sonerduzguner.com\/en\/wp-json\/wp\/v2\/posts\/3348\/revisions"}],"predecessor-version":[{"id":3459,"href":"https:\/\/www.sonerduzguner.com\/en\/wp-json\/wp\/v2\/posts\/3348\/revisions\/3459"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.sonerduzguner.com\/en\/wp-json\/wp\/v2\/media\/3354"}],"wp:attachment":[{"href":"https:\/\/www.sonerduzguner.com\/en\/wp-json\/wp\/v2\/media?parent=3348"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.sonerduzguner.com\/en\/wp-json\/wp\/v2\/categories?post=3348"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.sonerduzguner.com\/en\/wp-json\/wp\/v2\/tags?post=3348"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}