Cryptozoospermia

Cryptozoospermia is defined as the presence of fewer than 100,000 sperm in the initial analysis of the ejaculate semen from the male reproductive system or after washing, with only a few sperm seen in each field.
This condition makes the chance of natural pregnancy for couples almost impossible. When hormone levels are examined to investigate the cause in men, recombinant FSH (external supplementation), recombinant HCG, or Clomiphene treatment can be planned under the recommendation of an andrologist for individuals with low FSH hormone levels.
This condition can be confused with low semen volume in men, but it is unrelated. Even if the semen volume is low, it can still contain millions of sperm.
In cases where a man has extremely low sperm count, semen samples collected at different times may sometimes show no sperm at all, a condition known as aspermia. Sperm are considered dead if no movement is observed and if viability tests (HOST, Eosin staining) do not show any signs of life. This represents one of the most severe forms of male infertility. In this patient group, under the supervision of a male andrologist, all tests are conducted, and theophylline testing is applied to the collected samples to select motile sperm for use.
What is Crypto-Azoospermia?
Crypto Azoospermia, also known as Temporary Azoospermia, refers to the condition where some semen samples given intermittently at different times contain few sperm, while some samples show none, indicating azoospermia. In this patient group, the slow embryo development, especially from the 4th day onwards, may lead the IVF doctor to decide on directly retrieving sperm from the testis as the sperm source.
Here, a thorough physical examination, hormone tests, and imaging techniques in men will guide us regarding treatments that can increase sperm count.
Can Pregnancy Occur with Azoospermia?
Azoospermia is the absence of sperm in the male ejaculate semen. In this case, natural pregnancy for the woman is not possible. However, in IVF treatment, if sperm is surgically retrieved from the man's testis (with about a 58% chance of finding sperm), there is definitely a chance of pregnancy if a good embryo develops.
What Does Azoospermia Mean in Men?
Azoospermia in men refers to the absence of any sperm cells in the ejaculate. This reduces fertility. It is classified as obstructive or non-obstructive azoospermia. In both cases, surgical methods such as TESE (Testicular Sperm Extraction) or TESA (Testicular Sperm Aspiration) are used to retrieve sperm from the testis.
Cryptozoospermia Doctor's Advice
When diagnosed with cryptozoospermia, it is important to consult an experienced urologist or reproductive health specialist. The doctor will assess the individual’s condition and recommend appropriate treatment options. Since each person’s situation may differ, creating a personalized treatment plan requires expertise.
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Op. Dr. Soner DÜZGÜNER
Obstetrics and Gynaecology Specialist
Op. Dr. Soner Düzgüner: Provides diagnosis and treatment in areas such as in vitro fertilization, women's health, infertility, gynecological surgery and pregnancy follow-up.